Hi, my name is Bryce Thomas, and Welcome to my Blog

My name is Bryce Thomas, and I'm an aspiring Medical student. I live in Newbury, Berkshire. I started this Blog partly on the advice of a lecturer at Med-Link to document any work experience I have, or anything I hear about or discover that I am interested in.

Tuesday, 27 March 2012

Transplants


Oh my god! I’ve just watched this video on TED(an amazing website, full of fascinating things) and I saw this clip. Everything on this website is mind boggling, but this particular video, and especially the bit about the printing of cells just blew my mind.  
We live in an aging population. This means that where we once had a large proportion of relatively young people in the population, with extending life expectancy, the majority is shifting to a relatively large proportion of old people. With this comes all of the associated health problems – reduced immune function, loss of control over your body or mind, or failing organs. And this is what astonished me. This company or institute has pioneered, over the space of twenty years, the alternatives to organ transplant. I don’t mean the patient wouldn’t receive an organ, only that there would be no donor. The procedure as I understood it is this:
They take a biopsy of your failed organ. They rip it apart until you have groupings of cells and then they cultivate those. They know how the organ fits together, so using a biodegradable mould, they cultivate layers of the tissue needed – i.e. on a bladder, the inside of the mould has one kind of cell type, the outside has muscle tissue. They pour the cultivated muscle cells onto the framework on the outside, and the other cells into the framework on the inside. It goes into a kind of incubator which mimics the body’s conditions, and hey presto you have a new bladder. This was phenomenal, and if it can be applied to patients change the face of medicine. Patient has bowel cancer? Make them a new one. Patient has kidney failure? Make them a new one. Immunosuppressant drugs? Who needs those? Because the tissue is cultivated from your own cells there is no rejection.
But what prompted me to immediately get on the internet and blog about this was the printer. They took an inkjet printer (you may even have something similar on your desk right now) and swapped the cartridges around. They cracked the method, or formula for making this work, and then printed a heart. So it didn’t beat until a few hours later but it still happened, and they printed a heart! I can’t properly convey how excited and astounded I am by this notion, but I’m desperately trying to (I’ll be on here in an hour’s time, correcting spelling mistakes), but the idea that you can just manufacture your own organs and have a new one is extraordinary. If we had this technology now, then it’s possible that at least 30,000 lives could have been saved in 2010 alone*. This technology is so new and exciting, and it reminds me of why I want to become a doctor. The science, the idea of using science to help people, and the constant improvement of current methods are all features of medicine which I find more interesting than any other profession and are why I want to be a doctor.

*I did a little bit of research and found that over 30,000 people died in 2010 from problems to do with the cardiac system alone. This piece of information requires that I counted all of the relevant causes of death correctly, so it may be wrong. The figures themselves came from the government site here.

Saturday, 24 March 2012

Dissection - not for the squeamish

My dad knows that I'm interested in medicine, especially the anatomy side of things. We recently had a family of mice move into our shed at the bottom of the garden, so he killed one using a mouse trap, and bought me some equipment so that I could do a dissection. This is what I did. I used:
The equipment I used
The ratcheting pliers, scalpel, pins and tweasers


  • a craft knife (as a scalpel)
  • a pair of tweezers
  • a pair of ratcheting pliers (the ones I used were cast offs from my grandfathers fishing days)
  • a pack of pins
  • a pair of scissors
  • some cork board
  • a kilner jar
  • a couple of bottles of rubbing alcohol
  • some latex gloves
  • some newspaper to keep everything clean

The mouse, cork board, and kilner jar with some of the alcohol in it




















So following what I'd seen in this video, I opened up the mouse as best I could. So that I could see it all clearly, I pinned the mouse to the cork board. this means that it will stay open all the time. I found and identified all of the major organs, and I found something from almost all of the major systems in the body. There were a few things which I wasn't so sure about when I saw them (I may have found the mouse equivalent of the thyroid glands, and there was what I thought was a nerve cluster, but I wasn't sure), but I plan to show my biology teachers a photo, and ask them if they can identify them. The only major organ I didn't reach was the brain, which is a shame because I wanted to see if I could get it to have a look at it. Anyway, I really enjoyed it, and it's in my room, on a shelf.

A little explanation of what you can see: there is only a small part of the diaphragm left intact, as a lot had to be cut out so I could open the chest cavity. For the same reason, the left side of the ribcage and sternum are missing. The stomach is swollen and whitish yellow - this is not the normal state, but it's full of the cheese my dad baited the trap with. I was surprised by two things; the size of the heart and the testicles. Each testicle was probably bigger than the brain and heart combined (although I'm making an assumption about the brain. It's difficult to tell without taking a look, but the skull it quite small), and the heart was bigger than I thought it would be. There were two whitish lumps either side of the oesophegus and the trachea - I thought these might be thyroid glands. Anyone who has a better knowledge of anatomy than I do, feel free to correct me.

Annotated and dissected mouse

Tuesday, 20 March 2012

General

Just an update to keep this habit going!

I'm really happy at the moment. I've been talking with my reading mentor's tutor, and we've organised a way for me to make sure he gets to his sessions, because although I wait for him, he quite often doesn't turn up, so I'll post more about that later.

I've got some people who are finally responding positively to my work experience requests! I'm not going to say too much yet, I don't want to jinx it, but I'm very hopeful.

I'm due to give blood soon, and this will be my first time - I'm extremely excited. So that's all coming up.

I'm really enjoying my job up at the pub. I meet with the customers, and I have been learning to pull pints for them! It turns out I am allowed to serve alcohol to patrons but only under supervision. I really like the customer interaction because my previous job had next to none, but it's very interesting because of the variety of people who come in. We have a woman who I think has Parkinson's disease (though I haven't asked) and a self confessed alcoholic, among others. Most of the patrons are lovely and very easy to build up a rapport with. The customers which are a bit more stand offish are still very nice if you're courteous and polite to them, and it is sometimes possible to eventually get them to laugh along with you as well. #

Anyway, that's all for now! I'll post again soon!

Sunday, 18 March 2012

Down's Syndrome


This post has been a while coming but I wanted to research it properly as genetics is something that I am very interested in. Researching this has made me think of another possible career of research, if I get into Medical school.

Down’s syndrome

Down’s syndrome, named after the British physician who described it in 1866. It affects around 1/1000 babies in the UK (Down’s syndrome association website 18/3/12) and is more common in older women. It is also known as trisomy 21, referring to the extra chromosome which causes this disability. The baby is born with either an extra whole, or part of, chromosome 21. This occurs by chance at conception, and can be caused by faulty meiosis of the women’s eggs, where, in the final stages of meiosis one gamete has 3 chromosome 21s and the other only has one, or in familial Down’s syndrome, where part of chromosome 21 fuses to part of chromosome 14. The remaining genetic material is often lost in mitosis. This is called Robertsonian translocation. It is possible to carry this gene and be unaffected by Down’s as this only affects one gene from the homologous pair in carriers, and the “regular” gene can function as well by itself. 

Monosomy 21 (only one chromosome 21) seems much rarer, and often results in the infant dying fairly soon after birth. There are other trisomies which aren’t as common and can include trisomy 18 (Edward syndrome), 13 (Patau syndrome), or 8.

 It is possible to have partial or mosaic Down’s syndrome, or complete Down’s syndrome. Complete Down’s syndrome is as a result of a fault in meiosis, as stated above. Mosaic Down’s syndrome occurs when the foetus is developing. One of the cells divides but does so incorrectly, leaving one of the sister cells with an extra chromosome. This goes on to affect only part of the body, as opposed to complete Down’s where every cell has an extra chromosome. The third sub-type of Down’s is translocated or familial Down’s.
People with Down’s syndrome are usually easily recognised due to the prominent physical differences. Physical symptoms of Down’s include:
  • eyes that slant upwards
  • small ears
  • flat back of head
  • small mouth
  • protruding tongue
  • flattened nose bridge
  • white spots on the iris (the coloured part of the eye), known as Brushfield spots
  • short fingers
  • broad hands with a single crease across the palm
  • loose skin on the back of the neck
  • loose joints (babies in particular may seem ‘floppy’)
  • poor muscle tone (hypotonia)
  • low birth weight
  • vertical skin folds (epicanthic folds) between the upper eyelids and inner corner of the eye
Other symptoms include learning difficulties (memory problems, both short and long term, low attention spans, difficulty problem solving and difficulty understanding the consequences of their actions), and delayed development with “milestones” like learning to:
  • Read
  • Walk
  • Speak
  • And social skills
 There is no “cure” for Down’s (it is a disability, not a disease), but it is possible for the child to undergo treatment to help it with learning difficulties and other developmental problems, such as speech therapy. 

However, there are more severe complications which can occur as a result of Down’s. These include heart defects, 30% of which will be serious enough to need immediate attention after birth (NHS website 18/3/12), problems with hearing and vision, which affect around 50% of people born with Down’s, oral and thyroidal problems. Oral problems arise where the individual struggles to brush their teeth effectively or when they produce a lower level of saliva, allowing bacteria to damage gums and teeth. I found this particularly interesting as I didn’t even know that saliva helped with that. Thyroidal problems are when the person affected has hypothyroidism, where their thyroid doesn’t produce enough hormones. Your thyroid is responsible for your metabolism, or the rate at which chemical reactions take place in the body and as result can lead to weight gain, slow mental or physical reactions and dry or flaky skin, among others. It is possible for a person with Down’s to have hyperthyroidism, where the thyroid is overactive, but this is rarer. 

In conclusion, if intervention happens young, and the individual is offered sufficient support, both medically and educationally, there is very little reason for them not to be independent in at least some spheres of their adult life. I very much enjoy playing with the children at Mencap who have Down’s, and found them all fun loving and playful.

Sunday, 11 March 2012

Stress management

The following was part of a little research project I did as part of my homework in psychology, and because I thought it was interesting, I wanted to post it.

Psychological and physiological methods of stress management

Stress is a universal phenomenon, experienced by most people at some point during their lives. It can be brief and passing, or more chronic. People who experience chronic stress often suffer from specific medical complaints. This means that stress can be quantified, defined and measured.
The proper definition of stress is that of the transactional model of stress which is:
The perceived lack of fit between the demands of the situation and the person’s ability to cope
Stress is harmful for numerous reasons. When somebody undergoes a stress response it is because they perceive something as a threat to their safety. This was an evolutionary advantage when we hunted or were hunted as it allowed one of two actions to take place more effectively – that is, we were able to fight or run away. This is called the fight or flight stress response.  However, nowadays, one cannot simply fight or run away from whatever we perceive to be a threat because it could be something as simple as job insecurity or ambiguity, or other such stressors.
The end result is that the stress response which would once have been a short lived and temporary solution now does not work, but because you continue to be stressed, you continue to undergo the physiological changes which are attributed to flight or fight. These carry serious complications if they continue for too long, like an increased risk of coronary heart disease (CHD), and a lowered immune defence (Kiecolt-Glaser 1984)

Psychological methods of stress management

The psychological methods for dealing with stress include but are not limited to Meichenbaum’s stress inoculation training and Kobasa’s hardiness training.

Cognitive-behavioural therapy

This technique was devised to help individuals prepare for instances in the future where they may experience stress, and promotes resilience in patients. There are three main phases within this therapy. They are:
·         Conceptualisation
·         Skills training and practice
·         Real life application
Conceptualisation: This is where the patient is encouraged to remember and thoroughly recreate any previous events where they may have experienced stress. They are then asked to analyse it – what was their reaction? Was it successful? Why? This helps patients reach a more realistic understanding of the demands of the situation. That is, their perceived demands are reduced, and this reduces the stress of the situation.
Skills training and practice: this where, having identified the stressful aspects of the situation, the patient is expected to develop strategies to combat them. For instance, if they find job interviews stressful, they could practice job interviews and learn techniques to make themselves come across as a more viable candidate.
Real life application: this is where the training is put into effect without the therapist. Meetings are still arranged with the therapist to follow up, but the idea is that from here on, they should be able to go their own way.

Evaluation of the stress inoculation technique

Pros:
·         It works
·         It targets both sources of stress and symptoms
Cons:
·         It is expensive
·         It takes a long time
·         It is a difficult process

Kobasa’s hardiness training

Kobasa believed that hardiness was a measure of how well people could cope with stress and was a reason for the differences in peoples responses to stress and their potential physiological or psychological changes when they experienced prolonged stress.
Hardiness training is based around three key concepts of:
·         Focusing
·         Reliving stressful encounters
·         Self improvement
Focusing: this is where a patient is asked to pay attention to their body signals – sweating, raised heart beat, anxiety etc – so that they can identify stressful situations and can therefore deduce the source of the stress
Reliving stressful encounters: this is when they are encouraged to remember what the stressful event was and what they did about it; They are asked to imagine how it could have gone worse, to make them realise that their coping resources are not as bad as they could have been, and how they could have gone better, to improve their current coping strategies.
Self improvement: this is where the patient is encouraged to make reasonable and achievable goals. There will be problems within life which someone cannot cope with. By aiming for achievable goals the patient confirms to themselves that they do have control over their lives and lack of control can be a key cause of stress.

Evaluation of Kobasa’s hardiness training

Pros:
·           It appears to have a positive effect
Cons:
·         Takes time
·         Is expensive
·         The concept of “hardiness” is in dispute
·         Kobasa’s studies cannot be generalised – they only happened on white, middle class businessmen
·         Not many studies as to how effective it is

Physiological methods of treating stress


There are two methods of treating the physiological, both involving drugs. Because of the nature of the stress response which is a physiological one (meaning your body emits chemicals and changes how it works) the physiological response can be altered by introducing synthesised drugs into the equation. These can reverse the effect of the naturally produced hormones or block them, and act as inhibitors.

Benzodiazepines (BZ’s)

These are anti anxiety agents. They include, but are not limited to, drugs like Valium or Librium. They act directly on the brain and have a calming influence, reducing brain activity. They work by increasing the effect of an inhibitor, gamma amino butyric acid or GABA for short. GABA influences the brain on a neuronal level by making it calmer, or less excitable. BZ’s enhance gaba’s effectiveness, by acting as a pump for the chloride ions into the neurotransmitters. This means that other neuronal impulses are less effective. BZ’s work on about 40% of the brains neurones and can cause the body to relax. Impulses to or from the pituitary gland, for example, to release ACTH, could be inhibited. ACTH is one of the main hormones involved in the physiological stress response, and by inhibiting it you can calm the user down for a period of time.

Beta Blockers (BBs)

Beta blockers are another stress relieving drug. They do not work in the brain on a neuronal level like BZ’s, but in and around the body. They inhibit the hormones adrenaline and noradrenaline in the blood stream by competing for the same receptor sites. Adrenaline and noradrenaline are activated in the body’s physiological stress response. They stimulate beta-adrenergic receptors around the body, particularly in the heart, brain and blood vessels. When a body undergoes the stress response to a perceived threat they release the hormones adrenaline and noradrenaline. This causes the activation of the sympathetic ganglia (a process known as sympathetic arousal), part of the autonomic nervous system, which reduces blood flow to the stomach and other digestive organs, and increases blood pressure and heart rate, and allows the release of energy in the form of fats and sugars from the muscles where it is stored as glycogen. By taking BB’s they reduce the effect of adrenaline and noradrenaline and as a result the body does not experience sympathetic arousal. By competing for the same receptor sites the BBs stop adrenaline from increasing heart rate and blood pressure. This reduces the strain on the heart. BBs can also be taken by musicians and snooker players where “nerves” might make them jittery and reduce performance.

Evaluation of a drug based approach to treating stress

Pros
·         Instant effects
·         Clear and noticeable effects
·         Easily available
Cons
·         Dependency/addiction to the instant fix
·         Tolerance – the drugs have less effect the longer they are used. Higher doses are needed
·         Symptoms – drugs target the symptoms of the problem, not the source
·         Side effects – most anti anxiety drugs have side effects. BBs can be dangerous for individuals with serious asthma, and can contribute to type 2 diabetes

Alternative stress management techniques

These include physiological approaches which are not drugs and psychological ones which are alternatives to the ones stated above.

Progressive muscle relaxation technique (PMR)

Relaxing is often thought to be a natural process but it is in fact an art. A patient undergoing PMR would be encouraged to find a comfortable position and consciously contract and relax every muscle in their body, starting low down at the feet and working their way up. Eventually the patient is used to the sensations enough that they can recreate the feelings themselves and use it on an everyday basis. This allows the activation of the parasympathetic ganglia, a nervous pathway which enables digestion to take place, lowers blood pressure and heart rate. This is an alternative psychological stress management technique.

Evaluation of muscle relaxation technique

Pros
·         It can be very effective in reducing stress
Cons
·         It requires practise
·         It often is not practical (traffic jams can be stressful, using this technique would be difficult and inconvenient)
·         It’s time consuming
·         It targets the symptoms and not the problems

Biofeedback

This is a physiological technique used to treat stress. It involves someone being hooked up to a device which measures and reports blood pressure and heart rate, from information gathered from electrodes placed on the body. They are then encouraged to experiment themselves, and see which techniques they can use to lower either their blood pressure or their heart rate or both. Once they have proven to be able to consistently use a specific technique or combination of techniques they are then encouraged to try and utilise these in everyday life.

Evaluation of biofeedback

Pros
·         It can be very effective for particular individuals, especially children
Cons
·         It is expensive – it takes time to practise and the equipment needed is sophisticated
·         Some scientists have stated that it is no more effective than the other techniques like PMR without biofeedback, and that the addition of the machines do not help

In conclusion, the best approach would be to utilise one of the psychological methods of stress management which targets the source of the stress. Physiological methods can and should be used in certain circumstances (the build up to important life events causing severe stress) but should be a temporary measure, and dependant on the patient also attending and using the other methods.

Resources used

Psychology for AS (AQA) fourth edition published 2008 ISBN 978-0-00-725503-0
http://www.bcnc.org.uk/howtheywork.htm

Wednesday, 7 March 2012

Ethics

I recently read an article on the actions of a young male medical student, who was hiring himself out. I wanted to put forwards my own opinions. The original article is cited below.

I personally do not think that his actions were reprehensible. They were certainly controversial, and I do not think that it was the best way of approaching his problem but it was a valid one, and it worked. He now needs to decide though – whether he wishes to continue as a harlot, or, once he has financial stability, give it up and turn his full attention to medicine. 

While his act of hiring his body out was not in itself illegal or contemptible, the way in which he seems to play with the emotions of his clientele does not seem to be justified or empathetic. While he simply tells them what they want to hear, it seems that he is enjoying building a harem, and the power which comes with it. This kind of behaviour is not what would be expected from someone who claims to want to go into a caring profession. The other issue is that if he wanted to fund his course then there are plenty of other ways to do so. There are loads of possible bursaries, people who would be willing to sponsor him or even just donate – there are books which list funds you can apply to for activities based on sporting, education, science, art and more. 

I understand that he felt he had no choice but to sell himself at the time but I feel that now he has had enough time to accumulate funds to support himself, or to find an alternative method of earning money. Either way, to protect himself and his future career against any potentially harmful activities, he should stop.

http://student.bmj.com/student/view-article.html?id=sbmj.e906